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Matched Unrelated Donor (MUD): An Emerging need for Peripheral Blood Stem Cell Transplant-Juniper Publishers

Juniper Publishers- Open Access Journal of Case Studies

Matched Unrelated Donor (MUD): An Emerging need for Peripheral Blood Stem Cell Transplant

Authored by Vikash C Mishra

Background

Blood is a vital component of human body which is involved in many functions most importantly supplying oxygen along with essential nutrients to various parts of body to maintain the growth. It also acts as excretory mediator as it helps in elimination of waste by product. Blood is made up of four components commonly known as Red Blood Cells (RBC), plasma, platelets and White Blood Cells (WBC). Each component plays its important role to maintain the regulations in the human body. In case if there is any malfunctioning in either of these components, this leads to blood disorders. Common types of Blood Related Disorders (BRD) are Acute Lymphoblastic Leukemia (ALL), Acute Myelogenous Leukemia (AML), Chronic Lymphocytic Leukemia (CLL), Chronic Myelogenous Leukemia (CML), Hodgkin Lymphoma (HL), Non-Hodgkin Lymphoma (NHL), Severe Aplastic Anemia (SAA), Sickle cell disease (SCD) and Thalassemia.

Treatment Management available for the Patient

Chemotherapy

The most conventional method of treatment. Drugs that are often used to treat leukemia, lymphoma etc. In addition, it can also use for patient conditioning required for prior to stem cell transplant.

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Rehabilitative Care of Adult with Diabetes Mellitus-Juniper Publishers

Juniper Publishers- Open Access Journal of Case Studies

Rehabilitative Care of Adult with Diabetes Mellitus

Authored by Habtamu Sewunet Mekonnen

Abstract

Background: Diabetes of all types can lead to complications in many parts of the body and can increase the overall risk of dying prematurely. Possible complications include heart attack, stroke, kidney failure, leg amputation, vision loss and nerve damage. In pregnancy, poorly controlled diabetes increases the risk of fetal death and other complications

Aim: The main purpose of this study was to assess the rehabilitative care of a patient with diabetic mellitus

Result: diabetic patients need rehydration therapy, reversing electrolyte and acidosis, monitoring, blood pressure control, self-management education, psychosocial intervention, and family and social support as rehabilitation.

Conclusion: The rehabilitation care should be given at all levels of health care delivery system to improve lifelong quality of diabetic patient, by preventing diabetic related burdens including social, economic and psychological impacts of the disease

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Zoledronic Acid-Induced Acute Renal Failure in Multiple Myeloma-Juniper Publishers

JUNIPER PUBLISHERS-OPEN ACCESS JOURNAL OF CASE STUDIES

Zoledronic Acid-Induced Acute Renal Failure in Multiple Myeloma

Authored by Salem Bouomrani

  

Abstract

Introduction: Despite its potential severity, the renal toxicity induced by zoledronate acid (ZA) is poorly studied and little characterized in current medical practice. Acute renal failure with zoledronate in multiple myeloma (MM) has only been reported by a few authors as sporadic cases. We are reporting an original observation of ZA-induced early nephrotoxicity during MM treatment.

Case report: A 74-year-old female, with no notable pathological history, was explored for recent deterioration of the general condition with diffuse inflammatory rachialgia and bone pain. Investigations concluded to the diagnosis of IgG lambda Durie-Salmon stage IIIA MM. She was treated with six courses of melphalan-prednisolone-thalidomide (MPT) chemotherapy with a favorable initial outcome. The subsequent evolution was marked by the occurrence of two episodes of progression that were treated with two cycles of six MPT courses. Monthly infusions of ZA (Zometa®) at a dose of 4 mg were prescribed for very painful bone metastases. When admitted for the third infusion, the assessment noted acute renal failure with creatinine at 279μmol/l. Stopping Zometa® and adequate hydration allowed gradual normalization of renal function with creatinine at 194μmol/l after one week, 115μmol/l after one month, and 83μmol/l after two months.

Conclusion: ZA should be used with caution in MM, and regular monitoring of renal function is recommended. These measures are particularly useful if frequent administration of this drug, associated risk factors, and pre-existing renal lesions.

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