Abstract
Resistin is a member of a class of cystein-rich proteins collectively termed as resistin-like molecules. Resistin has been implicated in the pathogenesis of obesity-mediated insulin resistance and T2DM (Type II diabetes mellitus). In addition, resistin also appears to be a pro- inflammatory cytokine. Taken together, resistin, like many other adipocytokines, may possess a dual role in contributing to disease risk. However, to date there has been considerable controversy surrounding this 12.5kDa polypeptide in understanding its physiological relevance in both human and rodent systems. Furthermore, this has led question, whether resistin represents an important pathogenic factor in the etiology of T2DM or not. In this review, authors have made an attempt to discuss the key controversies and developments made so far towards the involvement of resistin molecule in the causation and progression of obesity and type II diabetes mellitus and factors associated with alteration in the expression of this magic molecule at physiological and genetic levels.
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