Abstract
Wolf’s isotopic response is defined as the occurrence of a new skin disease at the site of a previous treated or untreated skin disease, mostly herpes zoster. A 70-year-old man, presented with persistent lesions at the same location of previously healed herpes zoster infection. Histopathology revealed diffuse infiltration of signet-ring form neoplastic cells. Further evaluations confirmed gastric adenocarcinoma in the patient. Rare etiologies of Wolf`s isotopic response should be known by physicians and early histopathologic assay when face to this phenomenon in order to early diagnosis is essential.
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